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March 26, 2008
9780801888069
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Protein Crystallography

A Concise Guide

The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the remaining unknown proteins. This imaging technique uses the diffraction of X-rays to determine a protein's three-dimensional molecular structure.

Drawing on years of research and teaching experience, Eaton E. Lattman and Patrick J. Loll use clear examples and abundant illustrations to provide a concise and accessible primer on protein crystallography. Discussing the basics of diffraction, the behavior of two- and three-dimensional crystals, phase determination (including MIR and MAD phasing and molecular replacement), the Patterson function, and refinement, Lattman and Loll provide a complete overview of this important technique, illuminated by physical insights.

The crisp writing style and simple illustrations will provide beginner crystallographers with a guide to the process of unraveling protein structure.

About the Authors

Eaton E. Lattman is chair of the Department of Biophysics at the Johns Hopkins University and editor-in-chief of the journal Proteins: Structure, Function, and Genetics. Patrick J. Loll is the director of the Biochemistry Graduate Program at Drexel University College of Medicine.

Reviews

"A useful source."—Choice

"It is gratifying to see such a nice piece of work and the book is highly recommended."—Eddie Snell, Reflexions: Newsletter of the American Crystallographic Association

"One of the main assets of the book is its many illustrations. Without exception the figures are straightforward to interpret, and the visual support enables the newcomers to the field to follow the presented material easily."—Linda Schuldt and Manfred S. Weiss, Crystallography Reviews

The Johns Hopkins University Press

9780801888069 : protein-crystallography-lattman-loll
Hardback
152 Pages
$77.00 USD
9780801888083 : protein-crystallography-lattman-loll
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152 Pages
$40.00 USD
9780801896842 : protein-crystallography-lattman-loll
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152 Pages
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